The EACR Conference on Chromosomes in Crisis: From Chromosomal Instability to Catastrophes in Cancer Genomes will bring together leading experts to explore the mechanisms, consequences, and therapeutic vulnerabilities associated with these genomic rearrangements. Join us in Berlin, Germany, to uncover how chromosomal chaos shapes cancer biology and opens new avenues for clinical intervention.
Target audience
Basic and translational scientists and clinicians, both senior and young investigators from academia and industry, who are interested in various aspects of chromosome biology, chromosomal catastrophes and cancer.
Topics to be covered
- Genetics & genomics of chromosomal catastrophes
- Cell biology of chromosomal catastrophes
- Emerging technologies & model systems to measure and study chromosomal instability and its outcomes
- Therapeutic vulnerabilities & clinical opportunities
- Various types of chromosomal alterations, their formation, and their cellular consequences, including, but not limited to:
- Mechanisms of chromosome mis-segregation
- Chromosome instability (CIN)
- Whole-genome doubling (WGD)
- Aneuploidy
- Translocations and gene fusions
- Chromothripsis and structural rearrangements
- Telomere attrition
- ecDNA